Centromere |
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| Nucleus | Mitotic | Description | |
| Resting cells: Nucleoli: Mitotic region:Disease (antigens): |
Dots or ovoid granules spread over the nucleoplasm not visible Dots line up in the chromosome regionCREST syndrome, Scleroderma, primary biliary cirrhosis (centromere protein) |
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Coarse Speckled |
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| Nucleus | Mitotic | Description | |
| Resting cells: Nucleoli: Mitotic region:Disease (antigens): |
Coarse granular speckled fluorescence staining of the nucleoplasm Lack staining chromosomes negativeSLE (Sm), Mixed connective tissue disease (Sm), Sjögren’s disease (U4/U6-snRNP) |
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Discrete speckled |
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| Nucleus | Mitotic | Description | |
| Resting cells: Nucleoli: Mitotic region:Disease (antigens): |
Up to 5 or 10 dots of identical size in the nucleus. Not visible No stainingEarly marker of primary biliary cirrhosis, Chromic active hepatitis (few dots, up to 5 dots and sp100, up to 10 dots |
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Homogenous |
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| Nucleus | Mitotic | Description | |
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Resting cells: Nucleoli: Mitotic region:Disease (antigens): |
Smooth even staining of the nucleoplasm With or without masking of the nucleoli Condensed chromosomes are intensely stainedSLE (dsDNA, Histones), Rheumatoid arthritis (histones) |
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Nuclear Rim |
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| Nucleus | Mitotic | Description | |
| Negative | Resting cells:
Mitotic region: Disease (antigens): |
Membrane folds and thin nuclear rim can be clearly seen
Devoid of rim, negative SLE, chronic fatique syndrome, Scleroderma |
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Nuclear matrix |
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| Nucleus | Mitotic | Description | |
| Resting cells:
Mitotic region: Disease (antigens): |
Atypical speckling (large variable size) in a “sponge-like network” throughout the nucleoplasm. Condensed chromosomes are unstainedSLE, mixed connective tissue disease, rheumatoid arthritis and scleroderma (hnRNP) |
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Speckled |
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| Nucleus | Mitotic | Description | |
| Resting cells: Mitotic region:Disease (antigens): |
Granular speckled fluorescence staining (SS-A associated with fine while SS-B diffused speckling) NegativeSLE, Sjögren’s syndrome, chronic active hepatitis (SS-A (Ro), SS-B (La)) |
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